[et_pb_section fb_built=”1″ _builder_version=”4.7.7″ use_background_color_gradient=”on” background_color_gradient_start=”#00456f” background_color_gradient_end=”#005f89″ background_color_gradient_direction=”90deg” background_position=”bottom_center” custom_padding=”51.078125px|0px|0|0px|false|false”][et_pb_row column_structure=”3_5,2_5″ _builder_version=”4.7.7″ border_width_top=”40px” border_color_top=”#005f89″][et_pb_column type=”3_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.7.7″ text_font=”||||||||” text_text_color=”#ffffff” header_font=”|800|||||||” header_text_color=”#ffffff” header_font_size=”60px” header_2_font=”|300|||||||” header_2_text_color=”#ffffff” inline_fonts=”Trebuchet”]<\/p>\n
<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
by Emily Payne<\/p>\n
[\/et_pb_text][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/magazine.mcs.cmu.edu\/bio\/wp-content\/uploads\/sites\/3\/2020\/12\/tadique_andrei.png” title_text=”tadique_andrei” align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” _builder_version=”4.7.7″ max_width=”70%” border_color_all=”#1a2538″ border_width_bottom=”40px” border_color_bottom=”#005f89″ box_shadow_style=”preset1″][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.7.7″ use_background_color_gradient=”on” background_color_gradient_start=”#00456f” background_color_gradient_end=”#005f89″ background_color_gradient_direction=”90deg” custom_padding=”0|0px|33px|0px|false|false”][et_pb_row _builder_version=”4.7.7″ custom_padding=”50px|0px|26.015625px|0px|false|false”][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.7.7″ text_text_color=”#ffffff”]<\/p>\n
As the saying goes, Rome wasn\u2019t built in a day \u2014 and neither are vaccines. Something Andrei Tadique (S 2007) knows well. \u00a0<\/span><\/p>\n As a 13-year pharmaceutical and medical device industry veteran, Tadique has developed numerous vaccines and over-the-counter drugs, engineered manufacturing facilities and brought leading medical devices to market.\u00a0<\/span><\/p>\n And now as a senior manager at Emergent BioSolutions, Tadique is in the midst of possibly the most important work of his career \u2014 he\u2019s leading a team working on the manufacture of hundreds of millions of doses for four potential COVID-19 vaccines.\u00a0<\/span><\/p>\n The efforts are part of Operation Warp Speed (OWS), a directive to deliver 300 million doses of a safe, effective vaccine by January 2021.\u00a0<\/span><\/p>\n Headed by the Department of Health and Human Services (HHS), OWS has partnered with private companies and other federal agencies to invest in the development, clinical testing, manufacturing and distribution of promising COVID-19 vaccine candidates.\u00a0<\/span><\/p>\n As one of three HHS-designated Centers for Innovation in Advanced Development and Manufacturing, Emergent BioSolutions has partnered with Johnson & Johnson, AstraZeneca, Novavax and Vaxart to scale up and manufacture their vaccines. These centers were established in 2012 by HHS to develop and manufacture medical countermeasures in the face of public health emergencies.\u00a0<\/span><\/p>\n As the number of confirmed COVID-19 cases continues to climb both in the United States and worldwide, there\u2019s no doubt that creating a vaccine is imperative.\u00a0<\/span><\/p>\n But to do that, a process that would normally take upwards of a decade must be greatly accelerated.\u00a0<\/span><\/p>\n \u201cTypically, a pharmaceutical company would develop a vaccine, do years of clinical trials and then finally invest in manufacturing and distributing a vaccine,\u201d Tadique explained. Even then, he said, fewer than 10% of drugs that go through clinical trials are usually approved.\u00a0<\/span><\/p>\n To speed things up, each step of the process \u2014 developing, testing and manufacturing \u2014 is happening simultaneously.\u00a0<\/span><\/p>\n Sometimes working 12- to 14-hour days, Tadique spends his time speaking to scientists and engineers from each of the four companies. He wants to understand not only how to make their vaccines but how to transfer their technology from the lab bench to create a robust manufacturing platform to scale up the vaccines.<\/p>\n The endeavor is enormous but also remarkable.\u00a0<\/span><\/p>\n \u201cIt\u2019s a consortium of scientists and engineers all working together, collaborating to create something that has never been done before in the history of science,\u201d he said.\u00a0<\/span><\/p>\n At the same time, noted Tadique, this is high-stakes work. \u201cYou really have to pay attention to detail, understand each of these technologies and work hard to make sure that you designed it well enough that it\u2019s safe and stands up to regulatory scrutiny,\u201d he added.\u00a0<\/span><\/p>\n Though challenging, Tadique finds inspiration from the Carnegie Mellon University mantra: My heart is in the work. \u201cI want to do this job right because at the end of the day it\u2019s going to be my family and people I know that are going to be affected by the product I create,\u201d he said.\u00a0<\/span><\/p>\n Tadique also credits the Mellon College of Science for training him to think like a scientist. In his sophomore and junior year, the biological sciences major had two internships in the vaccines and biologics research group at Merck, which kickstarted his career in pharmaceuticals. \u201cI don\u2019t think I would have gotten that opportunity had I not been at CMU,\u201d he said.\u00a0<\/span><\/p>\n Since his days at CMU, Tadique has dreamed of using science to help others.\u00a0<\/span><\/p>\n \u201cI\u2019ve always wanted to do a job that has a huge impact on the world, and I\u2019m really grateful to be a part of this experience,\u201d he said.\u00a0<\/span><\/p>\n And when the next big challenge arises? \u201cI have no doubt that CMU is already helping prepare the next generation of scientists and engineers to tackle problems like this one.\u201d<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.22″ background_color=”#1f4c4c” custom_padding=”30px|0px|30px|0px|false|false” box_shadow_style=”preset6″][et_pb_row column_structure=”1_2,1_2″ _builder_version=”3.25″ custom_padding=”0|0px|0|0px|false|false”][et_pb_column type=”1_2″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_button button_url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjE2MzYifX0=@” button_text=”Research Roundup” _builder_version=”4.7.7″ _dynamic_attributes=”button_url” custom_button=”on” button_text_color=”#ffffff” button_border_color=”rgba(0,0,0,0)” button_icon=”%%2%%” button_icon_color=”#ffffff” button_icon_placement=”left” button_on_hover=”off” background_layout=”dark” button_border_color_hover=”rgba(0,0,0,0)” button_bg_color_hover=”#719f94″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”on” button_border_color__hover=”rgba(0,0,0,0)” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”on” button_bg_color__hover=”#719f94″ button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_button][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_button button_url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjE2MDMifX0=@” button_text=”Scott Keith Receives Graduate Fellowship” button_alignment=”right” _builder_version=”4.7.7″ _dynamic_attributes=”button_url” custom_button=”on” button_text_color=”#ffffff” button_border_color=”rgba(0,0,0,0)” button_icon=”%%3%%” button_icon_color=”#ffffff” button_on_hover=”off” background_layout=”dark” button_border_color_hover=”rgba(0,0,0,0)” button_bg_color_hover=”#719f94″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”on” button_border_color__hover=”rgba(0,0,0,0)” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”on” button_bg_color__hover=”#719f94″ button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" A PATH TO A VACCINE Alumnus Andrei Tadique heads the development of\u00a0scaling up promising COVID-19 vaccine candidates by Emily PayneAs the saying goes, Rome wasn\u2019t built in a day \u2014 and neither are vaccines. Something Andrei Tadique (S 2007) knows well. \u00a0 As a 13-year pharmaceutical and medical device industry veteran, Tadique has developed […]<\/p>\n","protected":false},"author":5,"featured_media":0,"parent":1322,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-1584","page","type-page","status-publish","hentry"],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/magazine.mcs.cmu.edu\/bio\/wp-json\/wp\/v2\/pages\/1584","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/magazine.mcs.cmu.edu\/bio\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/magazine.mcs.cmu.edu\/bio\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/magazine.mcs.cmu.edu\/bio\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/magazine.mcs.cmu.edu\/bio\/wp-json\/wp\/v2\/comments?post=1584"}],"version-history":[{"count":13,"href":"https:\/\/magazine.mcs.cmu.edu\/bio\/wp-json\/wp\/v2\/pages\/1584\/revisions"}],"predecessor-version":[{"id":1678,"href":"https:\/\/magazine.mcs.cmu.edu\/bio\/wp-json\/wp\/v2\/pages\/1584\/revisions\/1678"}],"up":[{"embeddable":true,"href":"https:\/\/magazine.mcs.cmu.edu\/bio\/wp-json\/wp\/v2\/pages\/1322"}],"wp:attachment":[{"href":"https:\/\/magazine.mcs.cmu.edu\/bio\/wp-json\/wp\/v2\/media?parent=1584"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}